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abstract::There is debate whether clinical trials with suboptimal power are justified and whether results from large studies are more reliable than the (combined) results of smaller trials. We quantified the error rates for evaluations based on single conventionally powered trials (80% or 90% power) versus evaluations based on ...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280212461098
更新日期:2016-04-01 00:00:00
abstract::The change-point model has drawn much attention over the past few decades. It can accommodate the jump process, which allows for changes of the effects before and after the change point. Intellectual disability is a long-term disability that impacts performance in cognitive aspects of life and usually has its onset pr...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280212463415
更新日期:2016-04-01 00:00:00
abstract::We consider two exact unconditional procedures to test the difference between two multinomials with ordered categorical data. Exact unconditional procedures are compared to other approaches based on the Wilcoxon mid-rank test and the proportional odds model. We use a real example from an arthritis pain study to illust...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280212450957
更新日期:2016-02-01 00:00:00
abstract::The analysis of fecundity data is challenging and requires consideration of both highly timed and interrelated biologic processes in the context of essential behaviors such as sexual intercourse during the fertile window. Understanding human fecundity is further complicated by presence of a sterile population, i.e. co...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280212438646
更新日期:2016-02-01 00:00:00
abstract::We propose a hierarchical Bayesian methodology to model spatially or spatio-temporal clustered survival data with possibility of cure. A flexible continuous transformation class of survival curves indexed by a single parameter is used. This transformation model is a larger class of models containing two special cases ...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280212445658
更新日期:2016-02-01 00:00:00
abstract::This article re-examines parametric methods for the calculation of time specific reference intervals where there is measurement error present in the time covariate. Previous published work has commonly been based on the standard ordinary least squares approach, weighted where appropriate. In fact, this is an incorrect...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280211426617
更新日期:2015-12-01 00:00:00
abstract::In many longitudinal studies, evaluating the effect of a binary or continuous predictor variable on the rate of change of the outcome, i.e. slope, is often of primary interest. Sample size determination of these studies, however, is complicated by the expectation that missing data will occur due to missed visits, earl...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280212437452
更新日期:2015-12-01 00:00:00
abstract::When comparing two different kinds of group therapy or two individual treatments where patients within each arm are nested within care providers, clustering of observations may occur in both arms. The arms may differ in terms of (a) the intraclass correlation, (b) the outcome variance, (c) the cluster size, and (d) th...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280214563100
更新日期:2015-10-01 00:00:00
abstract::This paper presents and compares several methods of measuring continuous baseline covariate imbalance in clinical trial data. Simulations illustrate that though the t-test is an inappropriate method of assessing continuous baseline covariate imbalance, the test statistic itself is a robust measure in capturing imbalan...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280211416038
更新日期:2015-04-01 00:00:00
abstract::In this paper, we describe a Bayesian hierarchical Poisson model for the prospective analysis of data for infectious diseases. The proposed model consists of two components. The first component describes the behavior of disease during nonepidemic periods and the second component represents the increase in disease coun...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280214527385
更新日期:2014-12-01 00:00:00
abstract::Estimating the long-term health impact of air pollution using an ecological spatio-temporal study design is a challenging task, due to the presence of residual spatio-temporal autocorrelation in the health counts after adjusting for the covariate effects. This autocorrelation is commonly modelled by a set of random ef...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280214527384
更新日期:2014-12-01 00:00:00
abstract::The Cochran-Armitage (CA) test is commonly used in both epidemiology and genetics to test for linear trend in two-way tables with a binary outcome. There has been increasing interest in the power and size of the test and in determination of sample size, especially when there is potential misclassification in the 'expo...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280211406424
更新日期:2014-06-01 00:00:00
abstract::Health data may be collected across one spatial framework (e.g. health provider agencies), but contrasts in health over another spatial framework (neighbourhoods) may be of policy interest. In the UK, population prevalence totals for chronic diseases are provided for populations served by general practitioner practice...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280212447150
更新日期:2014-04-01 00:00:00
abstract::Most statistical developments in the joint modelling area have focused on the shared random-effect models that include characteristics of the longitudinal marker as predictors in the model for the time-to-event. A less well-known approach is the joint latent class model which consists in assuming that a latent class s...
journal_title:Statistical methods in medical research
pub_type: 杂志文章,评审
doi:10.1177/0962280212445839
更新日期:2014-02-01 00:00:00
abstract::In this study, we discuss a decision theoretic or fully Bayesian approach to the sample size question in clinical trials with binary responses. Data are assumed to come from two binomial distributions. A Dirichlet distribution is assumed to describe prior knowledge of the two success probabilities p1 and p2. The param...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280211399562
更新日期:2013-12-01 00:00:00
abstract::We propose a cross-validated area under the receiving operator characteristic (ROC) curve (CV-AUC) criterion for tuning parameter selection for penalized methods in sparse, high-dimensional logistic regression models. We use this criterion in combination with the minimax concave penalty (MCP) method for variable selec...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280211428385
更新日期:2013-10-01 00:00:00
abstract::Guarding against false positive selections is important in many applications. We discuss methods based on subsampling and sample splitting for controlling the expected number of false positives and assigning p-values. They are generic and especially useful for high-dimensional settings. We review encouraging results f...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280211428371
更新日期:2013-10-01 00:00:00
abstract::Increasing the clinical applicability of functional neuroimaging technology is an emerging objective, e.g. for diagnostic and treatment purposes. We propose a novel Bayesian spatial hierarchical framework for predicting follow-up neural activity based on an individual's baseline functional neuroimaging data. Our appro...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280212448972
更新日期:2013-08-01 00:00:00
abstract::Cancer mortality risk estimates are essential for planning resource allocation and designing and evaluating cancer prevention and management strategies. However, mortality figures generally become available after a few years, making necessary to develop reliable procedures to provide current and near future mortality ...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280212446366
更新日期:2012-10-01 00:00:00
abstract::Researchers and clinicians often need to know whether a new method of measurement is equivalent to an established one that is already in use. For this problem, the estimation of limits of agreement advocated by Bland and Altman is a widely used solution. However, this approach ignores two vital issues in method compar...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280210379365
更新日期:2012-08-01 00:00:00
abstract::Estimation of the effect of a binary exposure on an outcome in the presence of confounding is often carried out via outcome regression modelling. An alternative approach is to use propensity score methodology. The propensity score is the conditional probability of receiving the exposure given the observed covariates a...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280210394483
更新日期:2012-06-01 00:00:00
abstract::Clinical trials investigating the efficacy of two or more doses of an experimental treatment compared to a single reference arm are not uncommon. In such situations, if each dose is compared to the reference arm using an un-adjusted significance level, consideration of the Type I familywise error is likely to be requi...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280210378943
更新日期:2011-12-01 00:00:00
abstract::This article aims to develop a probability-based model involving the use of direct likelihood formulation and generalised linear modelling (GLM) approaches useful in estimating important disease parameters from longitudinal or repeated measurement data. The current application is based on infection with respiratory sy...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280210385749
更新日期:2011-10-01 00:00:00
abstract::Statistical methods for carrying out asymptotic inferences (tests or confidence intervals) relative to one or two independent binomial proportions are very frequent. However, inferences about a linear combination of K independent proportions L = Σβ(i)p(i) (in which the first two are special cases) have had very little...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280209347953
更新日期:2011-08-01 00:00:00
abstract::Cancer patients are subject to multiple competing risks of death and may die from causes other than the cancer diagnosed. The probability of not dying from the cancer diagnosed, which is one of the patients' main concerns, is sometimes called the 'personal cure' rate. Two approaches of modelling competing-risk surviva...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280209347046
更新日期:2011-06-01 00:00:00
abstract::The threat of pandemics has made influenza surveillance systems a priority in epidemiology services around the world. The emergence of A-H1N1 influenza has required accurate surveillance systems in order to undertake specific actions only when and where they are necessary. In that sense, the main goal of this article ...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280210370265
更新日期:2011-04-01 00:00:00
abstract::This work presents a brief overview of Markov models in cancer screening evaluation and focuses on two specific models. A three-state model was first proposed to estimate jointly the sensitivity of the screening procedure and the average duration in the preclinical phase, i.e. the period when the cancer is asymptomati...
journal_title:Statistical methods in medical research
pub_type: 杂志文章,评审
doi:10.1177/0962280209359848
更新日期:2010-10-01 00:00:00
abstract::Repeated measures and multivariate outcomes are an increasingly common feature of trials. Their joint analysis by means of random effects and latent variable models is appealing but patterns of heterogeneity in outcome profile may not conform to standard multivariate normal assumptions. In addition, there is much inte...
journal_title:Statistical methods in medical research
pub_type: 杂志文章,评审
doi:10.1177/0962280209105016
更新日期:2010-06-01 00:00:00
abstract::We review recent work on the application of pseudo-observations in survival and event history analysis. This includes regression models for parameters like the survival function in a single point, the restricted mean survival time and transition or state occupation probabilities in multi-state models, e.g. the competi...
journal_title:Statistical methods in medical research
pub_type: 杂志文章,评审
doi:10.1177/0962280209105020
更新日期:2010-02-01 00:00:00
abstract::Comparison of sequences that have descended from a common ancestor based on an explicit stochastic model of substitutions, insertions and deletions has risen to prominence in the last decade. Making statements about the positions of insertions-deletions (abbr. indels) is central in sequence and genome analysis and is ...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280208099500
更新日期:2009-10-01 00:00:00
abstract::To project national hepatitis C virus (HCV) burden, unbiased estimation of HCV progression to liver cirrhosis is required for the whole community of HCV-infected individuals. However, widely varying estimates of progression rates to cirrhosis have been produced. This disparity is partly associated with the statistical...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280208094688
更新日期:2009-06-01 00:00:00
abstract::In this paper, a new allocation rule for treatment assignments in sequential clinical trials is proposed. The stratified and randomized play-the-winner rule (SRPWR) is an extension of the randomized play-the-winner rule to more than two treatments. It is applicable to cases where the probabilities of success of a trea...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280207081606
更新日期:2008-12-01 00:00:00
abstract::This paper is based on a conference presentation in which several authors presented results from analyses of the same dataset concerning the evaluation of progression-free survival (PFS) as a surrogate endpoint for overall survival in advanced colorectal cancer clinical trials. In evaluating a potential surrogate endp...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280207081860
更新日期:2008-10-01 00:00:00
abstract::Cluster randomized and multicentre trials evaluate the effect of a treatment on persons nested within clusters, for instance patients within clinics or pupils within schools. Although equal sample sizes per cluster are generally optimal for parameter estimation, they are rarely feasible. This paper addresses the relat...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280206079018
更新日期:2008-08-01 00:00:00
abstract::To evaluate the antiretroviral activity of antiretroviral agents and to compare the effects of two different antiretroviral agents, we propose a non-parametric mixed-effects model to investigate change of CD4+ counts. The proposed model and methods are applied to analyse the data from PACTG345 study. Population and in...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280206075524
更新日期:2008-04-01 00:00:00
abstract::Mixed models are widely used for the analysis of one repeatedly measured outcome. If more than one outcome is present, a mixed model can be used for each one. These separate models can be tied together into a multivariate mixed model by specifying a joint distribution for their random effects. This strategy has been u...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280206075305
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Dyspepsia diagnoses and treatment decisions are made in situations in which multiple factors must be taken into account. Evolving from neuro-biological insights, artificial neural networks (ANNs) can employ multiple factors in resolving medical prediction, classification, pattern recognition, and pattern com...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280206071839
更新日期:2007-08-01 00:00:00
abstract::It is now widely accepted that multiple imputation (MI) methods properly handle the uncertainty of missing data over single imputation methods. Several standard statistical software packages, such as SAS, R and STATA, have standard procedures or user-written programs to perform MI. The performance of these packages is...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280206074464
更新日期:2007-06-01 00:00:00
abstract::This paper is concerned with stochastic models for the spread of an epidemic among a community of households, in which individuals mix uniformly within households and, in addition, uniformly at a much lower rate within the population at large. This two-level mixing structure has important implications for the threshol...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1177/0962280206071643
更新日期:2006-10-01 00:00:00
abstract::Two tests are proposed for checking the linearity of nonparametric function in partially linear models. The first one is based on a Crámer-von Mises statistic. This test can detect the local alternative converging to the null at the parametric rate 1/square root n. A bootstrap resample technique is provided to calcula...
journal_title:Statistical methods in medical research
pub_type: 杂志文章
doi:10.1191/0962280206sm440oa
更新日期:2006-06-01 00:00:00